| Dimension | Scoring Notes | Score |
|---|---|---|
| Study Design | No published human trials. A small number of animal studies exist in rodent models examining tissue repair and anti-inflammatory effects, representing the extent of the published evidence base. Animal only score applies. The absence of a human safety study — let alone an efficacy trial — is the defining limitation. |
5 / 25 |
| Sample Size | No human participants. Animal study cohorts are small (typically 8–16 animals per group). Score is 0 for this dimension as no human efficacy data exists. |
0 / 20 |
| Replication | The limited animal studies that exist originate from a small number of groups, with no meaningful independent replication. Single study or single group at best. Score reflects the near-complete absence of a replication record. |
5 / 20 |
| Journal Impact Factor | The sparse published work appears in lower-tier journals or preprint form. No publications in peer-reviewed journals with meaningful impact factors have been identified for PDA-specific research. |
4 / 15 |
| Funding Independence | The available animal research does not appear to trace primarily to vendor or commercial interests — but the overall data volume is too thin to assess this dimension meaningfully. Score reflects the limited evidence available, not confirmed independence. |
4 / 10 |
| Population Diversity | Animal only — not applicable to human population diversity scoring. |
0 / 5 |
| Researcher h-Index | No prominent lead researcher with an established publication record specific to PDA has been identified. The compound is too new and too thinly researched to have a named academic investigator. Score is 1. |
1 / 5 |