| Dimension | Scoring Notes | Score |
|---|---|---|
| Study Design | Primarily in vitro and mouse/rat models for Alzheimer's, cardiovascular protection, and metabolic function. Some human correlational data (endogenous levels) but no intervention RCTs in humans. |
2 / 25 |
| Sample Size | No human intervention participants. In vitro and animal studies only for interventional evidence. |
0 / 20 |
| Replication | In vitro neuroprotective findings and animal studies replicated across multiple independent groups globally. Mitochondria-derived peptide field has active academic interest. |
15 / 20 |
| Journal Impact Factor | Published in PNAS (IF ~11), Nature Aging, Cell Metabolism. Parent mitochondria-derived peptide research has strong journal placement. |
8 / 15 |
| Funding Independence | NIH and academic funded. Independent research — Pinchas Cohen (USC) and others have NIH-backed programs. |
7 / 10 |
| Population Diversity | Animal/in vitro only. Not applicable. |
3 / 5 |
| Researcher h-Index | Pinchas Cohen (USC Dean of Gerontology) has h-Index 60+. The defining humanin researcher has a very strong profile. Capped at 5. |
2 / 5 |