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RQS Scoring Log

Creatine

Foundational Supplements· Human RCT· Scored May 2026· View compound profile →
93 /100
Strong Evidence
7 dimensions · 100 points total · Methodology by PeptideClear
Dimension Breakdown
DimensionScoring NotesScore
Study Design
Dozens of independent Human RCTs plus multiple meta-analyses across strength, cognition, recovery, and body composition. The ISSN position stand synthesizes hundreds of trials. Clearest 25/25 in the catalog.
25 / 25
Sample Size
Thousands of participants across the evidence base. Meta-analyses alone include hundreds per study.
20 / 20
Replication
Research groups across 20+ countries have independently replicated creatine's performance effects. Among the most replicated findings in sports nutrition.
20 / 20
Journal Impact Factor
Primary journals: JISSN (IF 3.7), Nutrients (IF ~4), Int J Sport Nutr Exerc Metab (IF ~4.6). Solid Q1 journals in their field.
12 / 15
Funding Independence
Mixed. Many studies independently funded through universities and NIH. However creatine supplement industry (Creapure, AlzChem) funds a meaningful portion.
7 / 10
Population Diversity
Studied across men and women, young athletes to elderly, multiple countries. Minor deduction for early foundational studies being predominantly male athletes.
4 / 5
Researcher h-Index
Richard Kreider (Texas A&M), lead creatine researcher, h-Index 83 with 28,000+ citations.
5 / 5