| Dimension | Scoring Notes | Score |
|---|---|---|
| Study Design | Extensively studied in rats and mice — gastric ulcer, tendon, ligament, nerve, and muscle repair models. No published human RCTs. One old Croatian human safety case series (not a trial). Animal only. |
5 / 25 |
| Sample Size | No human efficacy participants. Rat studies typically 8-12 animals per group. |
4 / 20 |
| Replication | Animal findings replicated extensively in Sikiric group (Zagreb) and some independent labs. However, the majority of animal research comes from a single research group — limiting independent replication score. |
5 / 20 |
| Journal Impact Factor | Most publications in Current Pharmaceutical Design (IF ~2), Journal of Physiology-Paris (IF ~2-3), and lower-tier journals. Not published in high-impact journals. |
4 / 15 |
| Funding Independence | Croatian academic and government funding (University of Zagreb). Independent from industry, but narrow geographic base. |
4 / 10 |
| Population Diversity | Animal only. Not applicable. |
0 / 5 |
| Researcher h-Index | Sikiric group (Zagreb) — Predrag Sikiric has a substantial h-Index (~30+) in peptide/GI research and is the defining researcher for this compound. |
1 / 5 |